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Association between serum level of urate and subclinical atherosclerosis: results from the SCAPIS Pilot.
Arthritis Research & Therapy ( IF 4.9 ) Pub Date : 2020-02-22 , DOI: 10.1186/s13075-020-2119-0 Panagiota Drivelegka 1 , Helena Forsblad-d'Elia 2 , Oskar Angerås 3, 4 , Göran Bergström 4, 5 , Caroline Schmidt 6 , Lennart T H Jacobsson 1 , Mats Dehlin 1
Arthritis Research & Therapy ( IF 4.9 ) Pub Date : 2020-02-22 , DOI: 10.1186/s13075-020-2119-0 Panagiota Drivelegka 1 , Helena Forsblad-d'Elia 2 , Oskar Angerås 3, 4 , Göran Bergström 4, 5 , Caroline Schmidt 6 , Lennart T H Jacobsson 1 , Mats Dehlin 1
Affiliation
BACKGROUND
Hyperuricemia is closely associated with cardiovascular disease (CVD). However, it has not been definitively established whether this association is independent of traditional cardiovascular risk factors (CVRFs) and whether it is gender-dependent. The aim of this study was to investigate in a population-based cohort (age range, 50-64 years) stratified by sex the association between the serum urate (SU) concentration and subclinical atherosclerosis, as reflected in the coronary artery calcification (CAC) score, common carotid intima-media thickness (CIMT), and carotid plaque score.
METHODS
The study involved participants in the Swedish CArdioPulmonary bioImage Study (SCAPIS) Pilot cohort (N = 1040; 48.8% males). This pilot cohort is part of the large population-based SCAPIS with 30,000 participants in the age range of 50-64 years, aimed at improving risk prediction for CVD. Subjects with a self-reported previous history of CVD (N = 68) or gout (N = 3) were excluded. The CAC score was assessed with the Agatston method using computed tomography. CIMT and carotid plaques were quantified by ultrasound. The associations between the SU quartiles and different levels of CAC, CIMT, and carotid plaques were assessed by multivariable logistic regression.
RESULTS
Age, BMI, education level, smoking, physical activity, hs-CRP, hypertension, and dyslipidemia showed no differences between males and females, while CAC (score > 0) and diabetes were both twice as common in men than in women (58% vs 26% and 8% vs 4%, respectively). Higher SU quartiles were in both sexes associated with BMI, hs-CRP, and the prevalence of hypertension, and in women, they were also associated with the prevalence of dyslipidemia. The three upper quartiles of SU (>308μmol/L) were linked to higher CAC scores in men, when adjusting for CVRFs, but not in women. CIMT and carotid plaques showed no correlation to SU in either sex.
CONCLUSIONS
Higher levels of SU are associated with the presence of CAC in men but not in women, whereas SU is not associated with CIMT or carotid plaques in either men or women. This implies that the biological effects of SU differ in men and women or that SU has varying effects on different vascular beds or during the different stages of the atherosclerotic process.
中文翻译:
尿酸盐的血清水平与亚临床动脉粥样硬化之间的关联:SCAPIS试验的结果。
背景技术高尿酸血症与心血管疾病(CVD)密切相关。然而,尚未确定这种关联是否独立于传统的心血管危险因素(CVRFs)以及它是否与性别有关。这项研究的目的是研究按性别分层的人群研究(年龄范围为50-64岁),血清尿酸(SU)浓度与亚临床动脉粥样硬化之间的关联,如冠状动脉钙化(CAC)评分,颈总内膜中层厚度(CIMT)和颈动脉斑块评分。方法该研究涉及瑞典CArdio肺生物图像研究(SCAPIS)试点队列的参与者(N = 1040;男性48.8%)。该试点队列是基于人口的大型SCAPIS的一部分,拥有30,000名年龄在50-64岁之间的参与者,旨在改善CVD的风险预测。自我报告既往有CVD史(N = 68)或痛风(N = 3)的受试者被排除在外。使用计算机断层扫描通过Agatston方法评估CAC评分。CIMT和颈动脉斑块通过超声定量。通过多变量logistic回归评估SU四分位数与不同水平的CAC,CIMT和颈动脉斑块之间的关联。结果年龄,BMI,教育程度,吸烟,体育锻炼,hs-CRP,高血压和血脂异常显示,男女之间无差异,而CAC(得分> 0)和糖尿病均是男性的两倍,是女性的两倍(58) %vs. 26%和8%vs 4%)。在BMI,hs-CRP和高血压患病率相关的男女中,SU的四分位数均较高,在女性中,它们也与血脂异常的患病率有关。调整CVRF时,男性的前三位四分位数(>308μmol/ L)与较高的CAC评分相关,而女性则无此意义。无论男女,CIMT和颈动脉斑块均与SU无相关性。结论较高的SU与男性中CAC的存在有关,而与女性无关,而SU与男性或女性中的CIMT或颈动脉斑块无关。这意味着SU的生物学作用在男人和女人中是不同的,或者SU对不同的血管床或在动脉粥样硬化过程的不同阶段具有不同的作用。结论较高的SU与男性中CAC的存在有关,而与女性无关,而SU与男性或女性中的CIMT或颈动脉斑块无关。这意味着SU的生物学作用在男人和女人中是不同的,或者SU对不同的血管床或在动脉粥样硬化过程的不同阶段具有不同的作用。结论较高的SU与男性中CAC的存在有关,而与女性无关,而SU与男性或女性中的CIMT或颈动脉斑块无关。这意味着SU的生物学作用在男人和女人中是不同的,或者SU对不同的血管床或在动脉粥样硬化过程的不同阶段具有不同的作用。
更新日期:2020-02-23
中文翻译:
尿酸盐的血清水平与亚临床动脉粥样硬化之间的关联:SCAPIS试验的结果。
背景技术高尿酸血症与心血管疾病(CVD)密切相关。然而,尚未确定这种关联是否独立于传统的心血管危险因素(CVRFs)以及它是否与性别有关。这项研究的目的是研究按性别分层的人群研究(年龄范围为50-64岁),血清尿酸(SU)浓度与亚临床动脉粥样硬化之间的关联,如冠状动脉钙化(CAC)评分,颈总内膜中层厚度(CIMT)和颈动脉斑块评分。方法该研究涉及瑞典CArdio肺生物图像研究(SCAPIS)试点队列的参与者(N = 1040;男性48.8%)。该试点队列是基于人口的大型SCAPIS的一部分,拥有30,000名年龄在50-64岁之间的参与者,旨在改善CVD的风险预测。自我报告既往有CVD史(N = 68)或痛风(N = 3)的受试者被排除在外。使用计算机断层扫描通过Agatston方法评估CAC评分。CIMT和颈动脉斑块通过超声定量。通过多变量logistic回归评估SU四分位数与不同水平的CAC,CIMT和颈动脉斑块之间的关联。结果年龄,BMI,教育程度,吸烟,体育锻炼,hs-CRP,高血压和血脂异常显示,男女之间无差异,而CAC(得分> 0)和糖尿病均是男性的两倍,是女性的两倍(58) %vs. 26%和8%vs 4%)。在BMI,hs-CRP和高血压患病率相关的男女中,SU的四分位数均较高,在女性中,它们也与血脂异常的患病率有关。调整CVRF时,男性的前三位四分位数(>308μmol/ L)与较高的CAC评分相关,而女性则无此意义。无论男女,CIMT和颈动脉斑块均与SU无相关性。结论较高的SU与男性中CAC的存在有关,而与女性无关,而SU与男性或女性中的CIMT或颈动脉斑块无关。这意味着SU的生物学作用在男人和女人中是不同的,或者SU对不同的血管床或在动脉粥样硬化过程的不同阶段具有不同的作用。结论较高的SU与男性中CAC的存在有关,而与女性无关,而SU与男性或女性中的CIMT或颈动脉斑块无关。这意味着SU的生物学作用在男人和女人中是不同的,或者SU对不同的血管床或在动脉粥样硬化过程的不同阶段具有不同的作用。结论较高的SU与男性中CAC的存在有关,而与女性无关,而SU与男性或女性中的CIMT或颈动脉斑块无关。这意味着SU的生物学作用在男人和女人中是不同的,或者SU对不同的血管床或在动脉粥样硬化过程的不同阶段具有不同的作用。