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Towards attaining a quantitative and mechanistic model of a cell.
Nature Reviews Molecular Cell Biology ( IF 112.7 ) Pub Date : 2020-02-21 , DOI: 10.1038/s41580-020-0229-9
Guillaume Diss 1
Affiliation  

Mutations cause phenotypic changes by perturbing the organization of molecular networks and the functions that emerge from these networks. A model of a cell based on molecular interactions will be required in order to understand the molecular mechanisms underlying complex traits. Mutations perturb molecular networks; thus, a model of molecular interactions will be required to fully understand complex phenotypes.

中文翻译:

致力于获得细胞的定量和力学模型。

突变通过扰动分子网络的组织和从这些网络中出现的功能而引起表型变化。为了理解复杂性状的分子机制,需要基于分子相互作用的细胞模型。突变扰动分子网络;因此,将需要一个分子相互作用的模型来充分理解复杂的表型。
更新日期:2020-02-21
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