Aromatics find a range of applications in the chemical, food, cosmetic and pharmaceutical industries. While production of aromatics on the current market heavily relies on petroleum-derived chemical processes or direct extraction from plants, there is an increasing demand for establishing new renewable and sustainable sources of aromatics. To this end, microbial cell factories-mediated bioproduction using abundant feedstocks comprises a highly promising alternative to aromatics production. In this review, we provide the recent development of de novo biosynthesis of aromatics derived from the shikimate pathway in yeasts, including the model Saccharomyces cerevisiae as well as other non-conventional species. Moreover, we discuss how evolved metabolic engineering tools and strategies contribute to the construction and optimization of aromatics cell factories.

中文翻译：

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利用酵母生产芳烃的现状：成就和挑战。

芳香族化合物在化学，食品，化妆品和制药行业有广泛的应用。尽管当前市场上的芳烃生产严重依赖于石油衍生的化学过程或直接从植物中提取，但建立新的可再生和可持续的芳烃来源的需求日益增长。为此，使用大量原料的微生物细胞工厂介导的生物生产是芳烃生产的极有前途的替代方法。在这篇综述中，我们提供了从酵母中iki草酸途径衍生的芳香族从头生物合成的最新进展，包括酿酒酵母模型以及其他非常规物种。此外，