Fluoromethyl groups, including tri‐, di‐, and mono‐fluoromethyl (CF₃, CF₂H, and CH₂F, respectively) groups, are important structural motifs in medicinal chemistry. Radical fluoromethylation has attracted significant interest for the late‐stage functionalization of complex bioactive molecules. Recently, light energy has been used for radical reactions in synthesis of various valuable products. Strategies using organic photocatalysts (OPCs) are beneficial for synthetic radical chemistry and various aspects of “sustainable development goals (SDGs)”. Particularly, over the past several years, considerable progress has been made in the field of photoinduced radical fluoromethylation by OPCs. In this minireview, the concepts of representative reaction systems for fluoromethyl radical generation will be discussed.

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可见光有机光催化自由基氟甲基化的前沿领域

氟甲基包括三氟，二氟和一氟甲基（分别为CF ₃，CF ₂ H和CH ₂ F）基团是药物化学中的重要结构基序。自由基氟甲基化引起了对复杂生物活性分子后期功能化的极大兴趣。最近，光能已用于合成各种有价值产物的自由基反应。使用有机光催化剂（OPC）的策略对于合成自由基化学和“可持续发展目标（SDG）”的各个方面都是有益的。特别是，在过去的几年中，通过OPC在光诱导的自由基氟甲基化领域已经取得了相当大的进步。s。在本小型复习中，将讨论用于生成氟甲基自由基的代表性反应系统的概念。