In this study, all‐solid‐state type potentiometric PVC membrane selective microsensor was developed for Metformin (MET) which is an antidiabetic drug active substance. Metformin‐tetraphenylborate (MET‐TPB) ion‐pair was used as an ionophore in the structure of the sensor membrane. It was determined that the sensor membrane at the ratio of 69 % o‐nitrophenyl octyl ether, 27 % polyvinyl chloride and 4 % MET‐TPB performed the best potentiometric performance. In a wide concentration range (1×10⁻⁵–1×10⁻¹ mol/L), the slope, detection limit, response time, pH range, and life‐time of the sensor were determined as 55.9±1.6 mV (R²=0.996), 3.35×10⁻⁶ mol/L, 8–10 s, pH: 3–8, and ∼10 weeks, respectively. The voltammetric performances of the sensor were also investigated. The prepared microsensor was successfully utilized for the determination of Metformin in a pharmaceutical drug sample by potentiometry and voltammetry. It was observed that the obtained results were in agreement with the results obtained by the UV spectroscopy method at 95 % confidence level.

中文翻译：

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全固态降糖药二甲双胍选择性微传感器的开发及其电化学应用

在这项研究中，开发了全固态型电位计PVC膜选择性微传感器，用于二甲双胍（MET），这是一种抗糖尿病药物活性物质。二甲双胍-四苯基硼酸酯（MET-TPB）离子对用作传感器膜结构中的离子载体。可以确定传感器膜的比率为69％邻硝基苯基辛基醚，27％聚氯乙烯和4％MET-TPB。在较宽的浓度范围（1×10 ^-5 –1×10 ^-1  mol / L）中，传感器的斜率，检测限，响应时间，pH范围和使用寿命确定为55.9±1.6 mV（R ² = 0.996），3.35×10 ^-6 mol / L，8-10 s，pH：3-8和约10周。还研究了传感器的伏安性能。制备的微传感器已成功用于电位计和伏安法测定药物样品中的二甲双胍。观察到的结果与在95％置信度下通过UV光谱法获得的结果一致。