B7-H3 as a newly identified costimulatory molecule that belongs to B7 ligand family, is broadly expressed in both lymphoid and non-lymphoid tissues. The overexpression of B7-H3 has been verified to be correlated with the poor prognosis and poor clinical outcome of several human cancers. In recent years, researchers reveal that B7-H3 is involved in the pathogenesis of various autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), Sjögren's syndrome (SS), ankylosing spondylitis (AS), etc. In this review, we will discuss the biological function of B7-H3 and summarize the progress made over past years regarding its role in the occurrence and development of autoimmune diseases. The insights gained from these findings could serve as the foundation for future therapies of these diseases.

中文翻译：

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B7-H3：自身免疫性疾病的有希望的治疗靶标。

B7-H3是属于B7配体家族的新发现的共刺激分子，在淋巴组织和非淋巴组织中均广泛表达。B7-H3的过表达已被证实与几种人类癌症的不良预后和不良的临床预后相关。近年来，研究人员发现B7-H3参与了各种自身免疫性疾病的发病机理，例如系统性红斑狼疮（SLE），类风湿关节炎（RA），多发性硬化症（MS），干燥综合征（SS），强直性脊柱炎（在本文中，我们将讨论B7-H3的生物学功能，并总结过去几年在其在自身免疫性疾病的发生和发展中所起的作用。从这些发现中获得的见识可以为这些疾病的未来治疗奠定基础。