Recent years have seen major advances in our ability to predict potential drug-drug interactions (DDIs) from the early stages of drug development, to their detection and possible prevention in clinical practice, through implementation of sophisticated electronic alerting and decision supporting systems. Conversely - an overwhelming prevalence of rejection of alerts by practicing physicians has been documented, along with a marked paucity of reports on the actual clinical consequences of these rejections - a gap in need of bridging.

中文翻译：

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对“华法林使用房颤或心脏瓣膜置换的华法林使用者暴露于双氯西林或氟氯西林的缺血性卒中和全身性栓塞”的评论。

近年来，我们通过先进的电子警报和决策支持系统，从药物开发的早期阶段到潜在的药物-药物相互作用（DDI）预测，检测和临床实践中的预防，已经取得了重大进展。相反，已经记录了执业医师拒绝警报的绝大多数情况，而且关于这些拒绝的实际临床后果的报告也很少，这需要桥接。