The review synthesised evidence examining the association between a. loneliness with inflammation and b. social isolation with inflammation in adults aged 16 or older from the general population. From an initial 7,400 articles we identified 14 papers that examined loneliness, and 16 that examined social isolation. Qualitative syntheses indicated mixed results, variable study quality, and methodological heterogeneity. Most studies provided associations for C-reactive protein CRP, fibrinogen and Interleukin-6 IL-6, and these results were synthesised using random-effects meta-analyses. There was no association between loneliness with CRP or fibrinogen, but there was a significant association between loneliness and IL-6 for most-adjusted but not least-adjusted analyses. There was also a significant least-adjusted association between social isolation with CRP and fibrinogen, which remained significant for fibrinogen in most-adjusted analyses. There was no association between social isolation with IL-6. Sensitivity analyses indicated that methodological heterogeneity impacted on results. Results indicate that social isolation and loneliness could be linked with systemic inflammation, but more robust methodology is needed to confirm these associations and unpack mechanisms.

中文翻译：

---

孤独，社交孤立与炎症之间的关联：系统评价和荟萃分析。

该综述综合了检查a。孤独与炎症和b。普通人群中16岁或以上成年人因炎症而与社会隔离。从最初的7,400篇文章中，我们确定了14篇研究孤独的论文和16篇研究了社会孤立的论文。定性综合表明结果不一，研究质量参差不齐，方法学也很不统一。大多数研究提供了C反应蛋白CRP，纤维蛋白原和白细胞介素6 IL-6的关联，这些结果是使用随机效应荟萃分析合成的。CRP或纤维蛋白原的寂寞之间没有关联，但是对于大多数调整但并非最少调整的分析，孤独与IL-6之间存在显着关联。CRP与社会隔离和纤维蛋白原之间的关系也存在最小调整的关联，在大多数调整后的分析中，这对纤维蛋白原仍然很重要。社会隔离与IL-6之间没有关联。敏感性分析表明，方法的异质性会影响结果。结果表明，社会孤立和孤独可能与系统性炎症有关，但是需要更强大的方法来确认这些关联和解开机制。