Transdermal drug delivery is an attractive and potentially more effective method of localized and systemic treatment with minimal side effects and greater safety than current techniques. However, a limitation of drug delivery through the skin is the presence of the stratum corneum, which inhibits the development of clinical applications. Furthermore, in order to achieve better therapeutic outcomes, a number of traditional topically-applied preparations have high drug concentrations which can lead to skin irritation and formation of lesions. The use of safer and milder hydrocortisone (HC) cream for the treatment of moderate to severe atopic dermatitis (AD) is not considered due to its low potency and poor absorption through the skin, even at a dose of 1%. Therefore, in the present study, a composite of HC-loaded micelles and carbomer hydrogel was designed to enhance transdermal HC transport to improve topical therapy of AD. Franz diffusion cell experiments indicated that this composite significantly increased the skin permeation rate and cumulative quantity of HC transferred, which were greater than a 9-fold and 50-fold increase relative to HC cream, respectively. In addition, the composite system was demonstrated to rapidly and effectively ameliorate inflammatory symptoms on an AD-like mouse model and greatly reduce skin irritation and adverse systemic effects compared to HC cream. As described above, the novel HC formulation was a feasible strategy to provide safe and effective treatment in AD therapy.

与目前的技术相比，透皮药物递送是一种有吸引力的且可能更有效的局部和全身治疗方法，其副作用最小且安全性更高。然而，通过皮肤递送药物的局限性在于角质层的存在，这抑制了临床应用的发展。此外，为了获得更好的治疗效果，许多传统的局部应用制剂具有较高的药物浓度，这会导致皮肤刺激和病变形成。不考虑使用安全，温和的氢化可的松（HC）乳霜治疗中度至重度特应性皮炎（AD），因为即使剂量为1％，它的功效也很低，并且无法通过皮肤吸收。因此，在本研究中，设计了载有HC的胶束和卡波姆水凝胶的复合物，以增强经皮HC的转运，从而改善AD的局部治疗。Franz扩散池实验表明，这种复合物显着提高了皮肤的渗透率和HC的累积转移量，相对于HC霜分别增加了9倍和50倍。此外，与HC霜相比，该复合系统被证明可快速有效地改善AD小鼠模型的炎症症状，并大大减少皮肤刺激和不利的全身作用。如上所述，新颖的HC制剂是在AD疗法中提供安全有效的治疗的可行策略。Franz扩散池实验表明，这种复合物显着提高了皮肤的渗透率和HC的累积转移量，相对于HC霜分别增加了9倍和50倍。此外，与HC霜相比，该复合系统被证明可快速有效地改善AD小鼠模型的炎症症状，并大大减少皮肤刺激和不利的全身作用。如上所述，新颖的HC制剂是在AD疗法中提供安全有效的治疗的可行策略。Franz扩散池实验表明，这种复合物显着提高了皮肤的渗透率和HC的累积转移量，相对于HC霜分别增加了9倍和50倍。此外，与HC霜相比，该复合系统被证明可快速有效地改善AD小鼠模型的炎症症状，并大大减少皮肤刺激和不利的全身作用。如上所述，新颖的HC制剂是在AD疗法中提供安全有效的治疗的可行策略。与HC霜相比，该复合系统被证明可快速有效地缓解AD小鼠模型的炎症症状，并大大减少皮肤刺激和不利的全身作用。如上所述，新颖的HC制剂是在AD疗法中提供安全有效的治疗的可行策略。与HC霜相比，该复合系统被证明可快速有效地缓解AD小鼠模型的炎症症状，并大大减少皮肤刺激和不利的全身作用。如上所述，新颖的HC制剂是在AD疗法中提供安全有效的治疗的可行策略。