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Isolation of new secondary metabolites from gorgonian soft coral Heteroxenia fuscescens collected from Red Sea
Phytochemistry Letters ( IF 1.7 ) Pub Date : 2020-02-20 , DOI: 10.1016/j.phytol.2020.02.006
Fahd M. Abdelkarem , Ezz-Eldin K. Desoky , Alaa M. Nafady , Ahmed E. Allam , Aldoushy Mahdy , Maki Nagata , Tomofumi Miyamoto , Kuniyoshi Shimizu

Further chemical study of the crude extract of the soft coral Heteroxenia fuscescens (Fam., Xeniidea), led to isolation of two new sterols, Heterofuscesterols A (1) and B (2), a sterol isolated for the first time from natural sources, 3β,5α,6β-trihydroxyandrosta-17-one (3), along with one new hydroperoxy sesquiterpene, Heterofusceterpene A (4), and one known ceramide (5). Their structures were elucidated by comprehensive spectroscopic analyses, including NMR and HRESIMS, and by comparison with previous data for related compounds in the literature. The cytotoxic activities of the isolated compounds were assessed using MTT colorimetric assay against MCF-7 and OVK-18 cancer cell lines.



中文翻译:

从红海中收集的戈尔贡软珊瑚杂种海藻中分离出新的次生代谢产物

进一步对软珊瑚杂种异花苜蓿(Feni。Xeniidea)的粗提物进行化学研究,导致分离出两种新的固醇,杂藻甾醇A(1)和B(2),这是首次从天然来源中分离出的固醇, 3 β,5 α,6 β -trihydroxyandrosta -17-酮(3)中,用一个新的过氧化氢倍半萜烯,Heterofusceterpene A(沿4),和一个已知的神经酰胺(5)。通过全面的光谱分析(包括NMR和HRESIMS),并与文献中相关化合物的先前数据进行比较,阐明了它们的结构。使用MTT比色测定法针对MCF-7和OVK-18癌细胞系评估分离的化合物的细胞毒性活性。

更新日期:2020-02-21
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