Three new 14-membered cembrane-type diterpenoids, jatrophainolides A–C (1−3), were isolated from the root bark of Jatropha integerrima Jacq. Thier structures were established on the basis of extensive spectroscopic techniques including NMR spectroscopy and mass spectrometry. Of these isolates, compounds 1 and 2 were a pair of isomers with the E/Z configurations of Δ^1,2 double bond. All compounds displayed potential inhibition against human protein tyrosine phosphatase 1B (PTP1B) with IC₅₀ values of 6.38, 25.9, and 27.4 μM, respectively.

中文翻译：

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麻风树素内酯A–C，新型麻风树型二萜，具有麻风树根皮的PTP1B抑制活性

三个新的14-元西松烷型双萜类，jatrophainolides A-C（1 - 3），从根皮分离麻疯integerrima黄灯笼。在包括核磁共振光谱和质谱在内的广泛光谱技术的基础上建立了它们的结构。这些分离物，化合物1和2分别为一对与所述异构体的E / Z Δ的配置^1,2-双键。所有化合物用IC酪氨酸磷酸酶1B（PTP1B）显示针对人蛋白的潜在抑制_50倍的6.38，25.9，和27.4的值μ分别男，。