As DNA sequencing and synthesis become cheaper and more easily accessible, the scale and complexity of biological engineering projects is set to grow. Yet, although there is an accelerating convergence between biotechnology and digital technology, a deficit in software and laboratory techniques diminishes the ability to make biotechnology more agile, reproducible, and transparent while, at the same time, limiting the security and safety of synthetic biology constructs. To partially address some of these problems, this paper presents an approach for physically linking engineered cells to their digital footprint-we called it digital twinning. This enables the tracking of the entire engineering history of a cell line in a specialized version control system for collaborative strain engineering via simple barcoding protocols.

中文翻译：

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将工程单元链接到其数字双胞胎：应变工程的版本控制系统。

随着DNA测序和合成变得更便宜且更容易获得，生物工程项目的规模和复杂性必将增长。然而，尽管生物技术和数字技术之间的融合正在加速，但是软件和实验室技术的不足削弱了使生物技术更加敏捷，可重现和透明的能力，同时限制了合成生物学构建体的安全性和安全性。 。为了部分解决其中一些问题，本文提出了一种将工程化细胞物理连接到其数字足迹的方法，我们称之为数字孪生。这使得可以通过简单的条形码协议在用于协作菌株工程设计的专用版本控制系统中跟踪细胞系的整个工程历史。