Although zwitterionic hydrogels exhibit excellent hemocompatibility, their extremely low tensile strength is an obstacle for their use in blood-contacting devices. Electrospun fiber scaffold-reinforced zwitterionic hydrogels are a possible solution to overcome the challenges of both mechanical strength and hemocompatibility. In this work, electrospun polyurethane (ePU) fiber scaffold-reinforced sulfobetaine methacrylate (SBMA) hydrogels (SRgels) were prepared. The SRgels exhibited 4.7 ± 0.5 MPa tensile fracture stress, while the interpenetration between the hydrogel and the fiber scaffold remained intact even under 2.8 MPa tensile stress at 3.0 mm mm-1 strain load; this confirms that the SRgels maintain excellent hemocompatibility for both blood cell adhesion and fibrinogen adsorption under physiological dynamic loading and that dynamically structural matching is achieved between the scaffold and the zwitterionic hydrogels. Mechano-induced self-enhancement was also observed after preloading more than 2.0 mm mm-1 tensile strain to resist fracture. In short, the preparation of SRgels can enable zwitterionic hydrogels to meet the requirement for mechanical strength in bio-applications as blood-contacting devices.

中文翻译：

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电纺聚氨酯支架增强的两性离子水凝胶作为生物相容性装置。

尽管两性离子水凝胶显示出极好的血液相容性，但其极低的拉伸强度是其在血液接触装置中使用的障碍。电纺纤维支架增强的两性离子水凝胶是克服机械强度和血液相容性挑战的可能解决方案。在这项工作中，制备了静电纺丝聚氨酯（ePU）纤维支架增强的甲基丙烯酸磺基甜菜碱（SBMA）水凝胶（SRgels）。SRgel表现出4.7±0.5 MPa的拉伸断裂应力，而在3.0 mm mm-1的应变载荷下，即使在2.8 MPa的拉伸应力下，水凝胶与纤维支架之间的互穿仍保持完整。这证实了SRgels在生理动态负荷下对于血细胞粘附和纤维蛋白原吸附均保持了出色的血液相容性，并且在支架和两性离子水凝胶之间实现了动态结构匹配。在预加载超过2.0 mm mm-1的拉伸应变以抵抗断裂后，还观察到了机械诱导的自我增强。简而言之，SRgels的制备可以使两性离子水凝胶满足生物应用中作为血液接触装置的机械强度要求。