Identification of an amino-terminus determinant critical for ryanodine receptor/Ca2+ release channel function,Cardiovascular Research

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Identification of an amino-terminus determinant critical for ryanodine receptor/Ca2+ release channel function
Cardiovascular Research ( IF 10.8 ) Pub Date : 2020-02-20 , DOI: 10.1093/cvr/cvaa043
Monika Seidel _{1,

2} , Camille Rabesahala de Meritens _{1,

2} , Louisa Johnson _{1,

2} , Dimitris Parthimos _{1,

3} , Mark Bannister _{1,

2} , Nia Lowri Thomas _{1,

4} , Esizaze Ozekhome-Mike _{1,

2} , Francis Anthony Lai ₅ , Spyros Zissimopoulos _{1,

2}

Affiliation

The cardiac ryanodine receptor (RyR2), which mediates intracellular Ca²⁺ release to trigger cardiomyocyte contraction, participates in development of acquired and inherited arrhythmogenic cardiac disease. This study was undertaken to characterize the network of inter- and intra-subunit interactions regulating the activity of the RyR2 homotetramer.

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