OBJECTIVES Transcranial Direct Current Stimulation (tDCS) is a new technology that is extensively used for migraine treatment. The present study aims to examine the effectiveness of cathodal-tDCS (c-tDCS) in decreasing migraine pain frequency, duration, and intensity at the right primary motor cortex (M1) or sensory cortex (S1) in individuals with episodic or chronic migraine. METHODS The present study has a randomized, single-blind, and sham-controlled design. It tests the effectiveness of 22 sessions of c-tDCS (20min/1000 μA) in 45 migraine patients (episodic = 35; chronic = 10/with aura = 28; without aura = 17). Spread over 10 consecutive weeks, the sessions started with three sessions per week and ended with one session per week. Participants were tested at the baseline, at the end of intervention, and at 12-month follow-up. The migraine diagnosis was based on criteria set by International Headache Society (IHS) and patients were allocated to two experimental (nm1 = 15; ns1 = 15) and a sham intervention group (nc = 15). RESULTS The results of a series of MANCOVAs showed a significant reduction (p < 0.05) in all hypothesized symptoms of migraine pain in both experimental groups compared to the sham intervention group at the posttest and follow-up. CONCLUSION The application of c-tDCS to M1 or S1 can be used as a technological intervention for the prophylactic and therapeutic treatment of episodic or chronic migraine. ETHICAL COMMITTEE REGISTRATION NUMBER Ir.mums.fm.rec.1396.362.

中文翻译：

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偏头痛中初级运动或感觉皮层的阴极 tDCS 的有效性：一项随机对照试验

目的 经颅直流电刺激 (tDCS) 是一种广泛用于偏头痛治疗的新技术。本研究旨在检查阴极​​ tDCS (c-tDCS) 在降低偶发性或慢性偏头痛患者右侧初级运动皮层 (M1) 或感觉皮层 (S1) 的偏头痛频率、持续时间和强度方面的有效性。方法 本研究采用随机、单盲和假对照设计。它测试了 45 名偏头痛患者（发作性 = 35；慢性 = 10/先兆 = 28；无先兆 = 17）的 22 次 c-tDCS（20 分钟/1000 μA）的有效性。这些课程持续 10 周，从每周 3 次课程开始，以每周 1 次课程结束。参与者在基线、干预结束和 12 个月的随访时接受了测试。偏头痛的诊断基于国际头痛协会 (IHS) 设定的标准，患者被分配到两个实验组（nm1 = 15；ns1 = 15）和一个假干预组（nc = 15）。结果 一系列 MANCOVA 的结果显示，与假干预组相比，在后测和随访中，两个实验组的所有假设的偏头痛症状均显着减少（p < 0.05）。结论 c-tDCS 对 M1 或 S1 的应用可用作预防和治疗发作性或慢性偏头痛的技术干预。道德委员会注册号 Ir.mums.fm.rec.1396.362。结果 一系列 MANCOVA 的结果显示，与假干预组相比，在后测和随访中，两个实验组的所有假设的偏头痛症状均显着减少（p < 0.05）。结论 c-tDCS 对 M1 或 S1 的应用可用作预防和治疗发作性或慢性偏头痛的技术干预。道德委员会注册号 Ir.mums.fm.rec.1396.362。结果 一系列 MANCOVA 的结果显示，与假干预组相比，在后测和随访中，两个实验组的所有假设的偏头痛症状均显着减少（p < 0.05）。结论 c-tDCS 对 M1 或 S1 的应用可用作预防和治疗发作性或慢性偏头痛的技术干预。道德委员会注册号 Ir.mums.fm.rec.1396.362。结论 c-tDCS 对 M1 或 S1 的应用可用作预防和治疗发作性或慢性偏头痛的技术干预。道德委员会注册号 Ir.mums.fm.rec.1396.362。结论 c-tDCS 对 M1 或 S1 的应用可用作预防和治疗发作性或慢性偏头痛的技术干预。道德委员会注册号 Ir.mums.fm.rec.1396.362。