Regular consumption of fruits and vegetables, which is related to high plasma levels of lipid-soluble micronutrients such as carotenoids and tocopherols, is linked to lower incidences of various age-related diseases. Differences in lipid-soluble micronutrient blood concentrations seem to be associated with age. Our retrospective analysis included men and women aged 22–37 and 60–85 years from the Berlin Aging Study II. Participants with simultaneously available plasma samples and dietary data were included (n = 1973). Differences between young and old groups were found for plasma lycopene, α-carotene, α-tocopherol, β-cryptoxanthin (only in women), and γ-tocopherol (only in men). β-Carotene, retinol and lutein/zeaxanthin did not differ between young and old participants regardless of the sex. We found significant associations for lycopene, α-carotene (both inverse), α-tocopherol, γ-tocopherol, and β-carotene (all positive) with age. Adjusting for BMI, smoking status, season, cholesterol and dietary intake confirmed these associations, except for β-carotene. These micronutrients are important antioxidants and associated with lower incidence of age-related diseases, therefore it is important to understand the underlying mechanisms in order to implement dietary strategies for the prevention of age-related diseases. To explain the lower lycopene and α-carotene concentration in older subjects, bioavailability studies in older participants are necessary.

定期食用水果和蔬菜与血浆中脂溶性微量营养素（如类胡萝卜素和生育酚）的高水平有关，可降低各种与年龄有关的疾病的发生率。脂溶性微量营养素血药浓度的差异似乎与年龄有关。我们的回顾性分析包括来自柏林老龄化研究II的22-37岁和60-85岁的男性和女性。参与者同时具有血浆样品和饮食数据（n = 1973）。年轻人和老年人之间的血浆番茄红素，α-胡萝卜素，α-生育酚，β-隐黄质（仅在女性中）和γ-生育酚（仅在男性中）之间存在差异。无论年龄大小，参与者之间的β-胡萝卜素，视黄醇和叶黄素/玉米黄质都没有差异。我们发现了番茄红素的重要关联，随着年龄的增长，α-胡萝卜素（均为倒数），α-生育酚，γ-生育酚和β-胡萝卜素（均为阳性）。调整BMI，吸烟状况，季节，胆固醇和饮食摄入量可以证实这些相关性，除了β-胡萝卜素。这些微量营养素是重要的抗氧化剂，并且与年龄相关疾病的发生率较低相关，因此，重要的是要了解其潜在机制，以实施饮食策略来预防年龄相关疾病。为了解释老年受试者中较低的番茄红素和α-胡萝卜素浓度，老年受试者的生物利用度研究是必要的。这些微量营养素是重要的抗氧化剂，并且与年龄相关疾病的发生率较低相关，因此，重要的是要了解其潜在机制，以实施饮食策略来预防年龄相关疾病。为了解释老年受试者中较低的番茄红素和α-胡萝卜素浓度，老年受试者的生物利用度研究是必要的。这些微量营养素是重要的抗氧化剂，并且与年龄相关疾病的发生率较低相关，因此，重要的是要了解其潜在机制，以实施饮食策略来预防年龄相关疾病。为了解释老年受试者中较低的番茄红素和α-胡萝卜素浓度，老年受试者的生物利用度研究是必要的。