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Hpv Impact On Oropharyngeal Cancer Patients Treated At The Largest Cancer Center From Brazil.
Cancer Letters ( IF 9.7 ) Pub Date : 2020-02-19 , DOI: 10.1016/j.canlet.2020.02.023
Luisa Aguirre Buexm 1 , Sheila Coelho Soares-Lima 2 , Paul Brennan 3 , Priscila Valverde Fernandes 4 , Monique de Souza Almeida Lopes 2 , Flávia Nascimento de Carvalho 2 , Izabella Costa Santos 5 , Luiz Fernando Dias 5 , Simone de Queiroz Chaves Lourenço 6 , Luis Felipe Ribeiro Pinto 2
Affiliation  

Oropharyngeal squamous cell carcinoma (OSCC) is a fatal and highly incident disease. Although tobacco and alcohol consumption are the main risk factors associated with OSCC, a recent significant increase in OSCC HPV16 positive cases in high-income countries has been observed. However, it is not clear whether this change is also present in low- and middle-income countries. In this study, we evaluated HPV16 prevalence in 346 OSCC cases diagnosed in the largest Brazilian oncology public hospital by using the combination of two techniques, HPV16 E6 detection by q-PCR and p16 immunohistochemistry. In total, 11.9% of cases were HPV16 E6 positive, 9.2% were p16 positive and 6.1% were positive in both analyses. There was a predominance of keratinizing-SCC, with only four HPV-positive cases showing basaloid-like or non-keratinizing-SCC. HPV infection had no impact on disease-free or overall survival, while alcohol use was an independent prognostic factor for overall survival. Most cases reported a high frequency of tobacco (94.6%) and alcohol consumption (88.2%), were of low education level, and typically presented at advanced clinical stages, indicating that the profile of Brazilian OSCC patients has not changed.

中文翻译:

HPV对巴西最大的癌症中心治疗的口咽癌患者的影响。

口咽鳞状细胞癌(OSCC)是一种致命的高发病率疾病。尽管吸烟和饮酒是与OSCC相关的主要危险因素,但最近在高收入国家中观察到OSCC HPV16阳性病例的显着增加。但是,目前尚不清楚中低收入国家是否也存在这种变化。在这项研究中,我们通过使用q-PCR检测HPV16 E6和p16免疫组织化学这两种技术的结合,评估了在巴西最大的肿瘤公立医院诊断的346例OSCC病例中的HPV16患病率。两项分析中,HPV16 E6阳性的病例总数为11.9%,p16阳性的病例为9.2%,p16阳性的病例为6.1%。角化性SCC占主导地位,只有4例HPV阳性病例显示类基底质或非角化性SCC。HPV感染对无病生存或总体生存没有影响,而饮酒是总体生存的独立预后因素。大多数病例报告吸烟率高(94.6%)和饮酒(88.2%),文化程度低,并且通常在临床晚期就诊,表明巴西OSCC患者的情况没有改变。
更新日期:2020-02-20
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