Adipose tissue and the liver play significant roles in the regulation of whole-body energy homeostasis, but they have not evolved to cope with the continuous, chronic, nutrient surplus seen in obesity. In this review, we detail how prolonged metabolic stress leads to adipose tissue dysfunction, inflammation, and adipokine release that results in increased lipid flux to the liver. Overall, the upshot of hepatic fat accumulation alongside an insulin-resistant state is that hepatic lipid enzymatic pathways are modulated and overwhelmed, resulting in the selective buildup of toxic lipid species, which worsens the pro-inflammatory and pro-fibrotic shift observed in nonalcoholic steatohepatitis.

中文翻译：

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脂肪-组织-肝脏相声在全身体代谢的控制中：对非酒精性脂肪肝的影响。

脂肪组织和肝脏在调节全身能量稳态中起着重要作用，但它们并不能发展为应对肥胖症中持续的，慢性的营养过剩。在这篇综述中，我们详细介绍了长时间的代谢应激如何导致脂肪组织功能障碍，炎症和脂肪因子释放，从而导致脂质向肝脏的通量增加。总体而言，伴随着胰岛素抵抗状态的肝脂肪积累的结果是，肝脂质酶途径被调节并被淹没，从而导致有毒脂质种类的选择性积累，这加剧了在非酒精性脂肪性肝炎中观察到的促炎性和促纤维化转变。