Patients with thyroid dysfunction (31 hypothyroid, 32 subclinical hypothyroidism, 34 hyperthyroid, and 30 subclinical hyperthyroidism) and 37 euthyroid control subjects were recruited and performed the attention network test (ANT), which can simultaneously examine the alertness, orientation and execution control of the participants. Patients with hypothyroidism had abnormalities in the alerting network, and those with hyperthyroidism had impairments of the alerting and executive control networks. No attention networks deficit existed in patients with subclinical hyperthyroidism and subclinical hypothyroidism. The anxiety and depression scores of patients with thyroid dysfunction were significantly higher than those of the healthy control group. Covariance analysis demonstrated that interactions between group and Hamilton Anxiety Scale scores, group and HAMD score were not significant, but there was a significant main effect for group when analyzing the difference in values of the alerting network between groups. Further, the efficiency of the executive control network was negatively correlated with the T4 level in the hypothyroidism group, and positively correlated with the T4 level in the hyperthyroidism group. T4 or T3 level and efficiencies of the executive control network had a significant quadratic U-shaped relationship in all participants. In summary, the patients with four kinds of thyroid dysfunction exhibited different characteristics of ANT performance. Patients with thyroid dysfunction had various degrees of anxiety and depression disorders, but anxiety and depression disorders had no effect on the differences in the executive control network between the groups.

中文翻译：

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甲状腺功能障碍患者的注意力网络改变：一项神经心理学研究。

招募患有甲状腺功能障碍的患者（31例甲状腺功能减退，32例亚临床甲状腺功能减退，34例甲状腺功能亢进和30例亚临床甲状腺功能亢进）并进行注意力网络测试（ANT），该网络可以同时检查患者的警觉性，方向和执行控制参与者。甲状腺功能低下的患者的警报网络异常，甲状腺功能亢进的患者的警报和执行控制网络受损。亚临床甲状腺功能亢进和亚临床甲状腺功能减退症患者没有注意网络缺陷。甲状腺功能低下患者的焦虑和抑郁评分明显高于健康对照组。协方差分析表明，小组与汉密尔顿焦虑量表评分之间存在相互作用，组和HAMD得分均不显着，但在分析组之间警报网络值的差异时，组具有显着的主要影响。此外，在甲状腺功能减退组中，执行控制网络的效率与T4水平呈负相关，在甲状腺功能亢进组与T4水平呈正相关。在所有参与者中，T4或T3级别和执行控制网络的效率具有显着的二次U型关系。综上所述，四种甲状腺功能不全患者表现出不同的ANT性能特征。甲状腺功能不全的患者有不同程度的焦虑和抑郁症，但是焦虑和抑郁症对两组之间执行控制网络的差异没有影响。