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Development and Evaluation of Biomimetic 3D Coated Composite Scaffold for Application as Skin Substitutes
Macromolecular Materials and Engineering ( IF 3.9 ) Pub Date : 2020-02-20 , DOI: 10.1002/mame.201900848
Sui‐Hong Liu 1, 2, 3 , Hai‐Guang Zhang 1, 2, 3 , Qing‐Xi Hu 1, 2, 3 , Ben Wang 4, 5, 6 , Shuai Li 1, 2, 3 , Chuck Zhang 4, 5, 6
Affiliation  

Skin injuries are an urgent health issue, which raises a great concern in the clinic. Although numerous strategies have been proposed to fabricate skin substitutes for treatment of wounds over the past several decades, fabricating an ideal skin substitute to replace the damaged one can still be a problem. In this study, a novel biomimetic 3D composite skin scaffold is fabricated by combining electrohydrodynamic (EHD) jetting, electrospinning, and coating techniques. Here, the first polycaprolactone (PCL) porous structure is produced by the EHD jetting. Next, the second polylactic acid (PLA) membrane consisted of nanoscale fibers is prepared on the PCL porous structure via the electrospinning. The PCL porous structure and PLA fibers membrane can mimic the dermis and epidermis layer, respectively. Furthermore, gelatin is used as coating solution to enhance the biocompatibility of the scaffold. The structure and morphology of the fabricated scaffolds are analyzed, and the mechanical properties are investigated as well. Moreover, the in vitro and in vivo experiments demonstrate the biocompatibility of the materials and the fabrication process. In conclusion, these results demonstrate that the composite scaffold is effective and holds great potential for skin regeneration in the clinic.

中文翻译:

仿生3D涂层复合支架材料的开发与评价

皮肤伤害是紧急的健康问题,这在临床中引起了极大的关注。尽管在过去的几十年中已经提出了许多策略来制造皮肤替代物来治疗伤口,但是制造理想的皮肤替代物来替代受损的皮肤仍然是一个问题。在这项研究中,通过结合电动流体动力学(EHD)喷射,静电纺丝和涂覆技术,制造了一种新型的仿生3D复合皮肤支架。在此,通过EHD喷射产生第一聚己内酯(PCL)多孔结构。接下来,通过电纺丝在PCL多孔结构上制备由纳米级纤维组成的第二聚乳酸(PLA)膜。PCL多孔结构和PLA纤维膜可以分别模拟真皮层和表皮层。此外,明胶用作包衣溶液以增强支架的生物相容性。分析了所制备支架的结构和形态,并研究了其力学性能。而且,体外和体内实验证明了材料的生物相容性和制造过程。总之,这些结果表明复合支架是有效的,并且在临床上具有巨大的皮肤再生潜力。
更新日期:2020-03-12
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