当前位置: X-MOL 学术Rapid Commun. Mass Spectrom. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A sensitive and cost‐effective high‐performance liquid chromatography/tandem mass spectrometry (multiple reaction monitoring) method for the clinical measurement of serum hepcidin
Rapid Communications in Mass Spectrometry ( IF 2 ) Pub Date : 2020-02-20 , DOI: 10.1002/rcm.8644
Michael Chen 1, 2, 3 , Jun Liu 2 , Bruce Wright 3
Affiliation  

Hepcidin is a peptide hormone that plays a central role in regulating iron metabolism. It is a potential biomarker for the diagnosis, monitoring and treatment of iron metabolism disorders. Serum hepcidin level can differ by 3 orders of magnitude depending on the patient's condition. Existing liquid chromatography/mass spectrometry (LC/MS) assays lack clinical sensitivity or require costly sample preparation steps. A simple, sensitive, robust and cost‐effective assay for serum hepcidin quantitation in routine clinical laboratories is needed.

中文翻译:

一种灵敏且经济高效的高效液相色谱/串联质谱(多反应监测)方法,用于血清铁调素的临床测量

铁调素是一种肽激素,在调节铁代谢中起着核心作用。它是诊断,监测和治疗铁代谢异常的潜在生物标志物。血清铁调素水平可以根据患者的状况而相差三个数量级。现有的液相色谱/质谱(LC / MS)分析缺乏临床敏感性或需要昂贵的样品制备步骤。需要在常规临床实验室中进行简单,灵敏,可靠且经济高效的血清铁调素定量测定方法。
更新日期:2020-02-20
down
wechat
bug