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Simple and sensitive method for the analysis of 14 antituberculosis drugs using liquid chromatography/tandem mass spectrometry in human plasma
Rapid Communications in Mass Spectrometry ( IF 2 ) Pub Date : 2020-02-19 , DOI: 10.1002/rcm.8667
Qian Lei 1 , Yuan Zhao 1 , Hao Wang 1 , Jun Zhou 1 , Xiaohui Lv 1 , Liyun Dang 1 , Changsheng Zhu 1
Affiliation  

Monitoring plasma concentration and adjusting doses of antituberculosis (TB) drugs are beneficial for improving responses to drug treatment and avoiding adverse drug reactions. A simple and sensitive liquid chromatography/tandem mass spectrometry method was developed to measure the plasma concentrations of 14 anti‐TB drugs: ethambutol, isoniazid, pyrazinamide, levofloxacin, gatifloxacin, moxifloxacin, prothionamide, linezolid, rifampin, rifapentine, rifabutin, cycloserine, p‐aminosalicylic acid, and clofazimine.

中文翻译:

液相色谱/串联质谱法测定人血浆中14种抗结核药物的简单而灵敏的方法

监测血浆浓度和调整抗结核药物的剂量有助于改善对药物治疗的反应并避免药物不良反应。一个简单的和敏感的液相色谱/串联质谱法的开发是为了测量14抗结核药物的血浆浓度:乙胺丁醇,异烟肼,吡嗪酰胺,左氧氟沙星,加替沙星,莫西沙星,丙硫,利奈唑胺,利福平,利福喷汀,利福布汀,环丝氨酸,p -氨基水杨酸和氯法齐明。
更新日期:2020-02-20
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