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Brachyury: Strategies for Drugging an Intractable Cancer Therapeutic Target
Trends in Cancer ( IF 18.4 ) Pub Date : 2020-02-19 , DOI: 10.1016/j.trecan.2020.01.014
Helena Robinson , Ramsay J. McFarlane , Jane A. Wakeman

New approaches to drug discovery are unlocking enormous therapeutic potential residing in cancer-specific molecules. Brachyury is emerging as an exciting new drug target for the rare bone cancer chordoma. Here, recent advances targeting Brachyury in chordoma are discussed and how these might open doors to the targeting of other, more common cancer types.



中文翻译:

Brachyury:药物治疗顽固性癌症治疗目标的策略

药物发现的新方法正在释放存在于癌症特异性分子中的巨大治疗潜力。Brachyury正在成为一种罕见的骨癌脊索瘤令人兴奋的新药物靶标。在这里,讨论了针对脊索瘤中Brachyury的最新进展,以及这些进展如何为靶向其他更常见的癌症类型打开大门。

更新日期:2020-02-19
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