Glioma is the most common tumor of the central nervous system; variation in susceptibility and prognosis worldwide suggests that there are molecular and genetic differences among individuals. The H19 gene plays a dual role in carcinogenesis. In this study, associations between H19 polymorphisms and susceptibility as well as prognosis in glioma were evaluated. In total, 605 patients with glioma and 1,300 cancer-free subjects were enrolled in the study. Individuals with the rs3741219 A>G allele were less likely to develop glioma (relative risk [RR] = 0.54, 95% confidence interval [95% CI] = 0.45–0.63, p < 0.001), whereas rs217727 G>A and rs2839698 G>A genotypes were not associated with glioma risk. The associations between H19 polymorphisms and prognosis were assessed, including overall survival and progression-free survival. Three focused H19 polymorphisms did not show a significant effect on survival. Further analysis based on false-positive report probability validated these significant results. In the haplotype analysis, individuals with the G_rs217727A_rs2839698G_rs3741219 haplotype were less likely to develop glioma (odds ratio [OR] = 0.33, 95% CI = 0.23–0.46, p = 0.02). Overall, carriers of the rs3741219 AG or GG genotype of H19 have a decreased susceptibility to glioma, but polymorphisms in this gene are not related to prognosis.

神经胶质瘤是中枢神经系统最常见的肿瘤。世界各地的敏感性和预后差异表明个体之间存在分子和遗传差异。在H19基因在肿瘤发生的双重角色。在这项研究中，H19基因多态性与脑胶质瘤的易感性和预后之间的关联进行了评估。共有605名神经胶质瘤患者和1,300名无癌受试者参加了研究。rs3741219 A> G等位基因的个体发生神经胶质瘤的可能性较小（相对风险[RR] = 0.54，95％置信区间[95％CI] = 0.45-0.63，p <0.001），而rs217727 G> A和rs2839698 G > A基因型与胶质瘤风险无关。H19之间的关联评估多态性和预后，包括总生存期和无进展生存期。三个聚焦的H19多态性未显示对生存的显着影响。基于假阳性报告概率的进一步分析验证了这些重要结果。在单倍型分析中，具有G _rs217727 A _rs2839698 G _rs3741219单倍型的个体发生神经胶质瘤的可能性较小（优势比[OR] = 0.33，95％CI = 0.23-0.46，p = 0.02）。总体而言，rs3741219 AG或H19 GG基因型的携带者对神经胶质瘤的敏感性降低，但该基因的多态性与预后无关。