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Acne vulgaris and risk of depression and anxiety: A meta-analytic review.
Journal of the American Academy of Dermatology ( IF 7.102 ) Pub Date : 2020-02-20 , DOI: 10.1016/j.jaad.2020.02.040
Danielle V Samuels,Robert Rosenthal,Rick Lin,Soham Chaudhari,Misaki N Natsuaki

BACKGROUND Several studies have shown an association of acne vulgaris with depression and anxiety but a quantitative review has not yet been conducted. OBJECTIVE To conduct a systematic review and meta-analysis that elucidates the association of acne vulgaris with depression and anxiety. METHOD A systematic review and meta-analysis of literature published prior to October 1, 2019 from PubMed, PsycINFO, MEDLINE, and Cochrane databases was conducted. We used a meta-analytic approach to perform a random effects analysis comparing individuals with and without acne. Subgroup analyses between studies included age, study setting, and geographic region. RESULTS In all, 42 studies were included. We found a significant association of acne vulgaris with depression, r = 0.22 (95% CI: 0.17-0.26, p < .00001), and anxiety, r = 0.25 (95% CI: 0.19-0.31, p < .00001). Subgroup analyses and comparisons showed moderating influences based on factors including age, study setting, and geographic region. LIMITATIONS Inconsistency between publications regarding acne and outcome ascertainment, data reporting, and studies with no control group posed considerable barriers to synthesizing all available literature. CONCLUSION Because of increased risk for depression and anxiety, clinicians should pursue aggressive treatment of acne and consider psychiatric screening or referrals.
更新日期:2020-02-20

 

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