BACKGROUND Obesity is a major public health problem whose prevalence has been rapidly increasing in the United States (U.S), and globally. It is one of the leading causes of preventable deaths globally and contributes to the development of many diseases. METHODS The search was limited to studies published in English and other languages involving both animal and human subjects. Articles selected included preclinical studies, randomized clinical trials RCTs, observational studies, meta-analyses, narrative and systemic reviews providing primary quantitative data with a measure of obesity or food addiction as an outcome. Over 5000 articles were found in the first round of search which was filtered to 506 articles. RESULTS Oxidative stress plays a critical role in food addiction and is both a cause and mediator of obesity. Reactive oxygen species play a direct role in adipogenesis and oxidative stress modulates all factors involved in obesity including genetics, sleep, gut microbiome, insulin, ghrelin, inflammation, adipokines, leptin, stress, HPA axis, and the hypothalamus. CONCLUSIONS The idea of thinking of combating obesity from the lens of calorie count, low carbohydrate, high or low-fat, vegetarian, vegan, plant-based, or animal-based diet is fundamentally wrong. The best way to look at obesity is through the framework of systemic redox homeostasis. Since redox homeostasis is tilted towards increased reactive oxygen species production, and excessive antioxidant intake can result in oxidative stress, an antioxidant and prooxidant food ratio of 2:3 per meal is the ideal nutritional ratio for good health and ideal weight. A ratio of 3:4 is ideal for obese individuals because of their state of chronic oxidative stress and inflammation. Physical activity, sleep quality, psychological stress, maternal prenatal diet and oxidative stress promoting disease conditions are important modulators of oxidative stress and obesity.

中文翻译：

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建立肥胖症和健康饮食的综合理论：氧化应激在食物成瘾和肥胖中的因果作用。

背景技术肥胖症是主要的公共卫生问题，在美国和全球范围内，其患病率都在迅速增加。它是全球可预防死亡的主要原因之一，并助长了许多疾病的发展。方法该搜索仅限于以英语和其他语言发表的涉及动物和人类受试者的研究。所选择的文章包括临床前研究，随机临床试验RCT，观察性研究，荟萃分析，叙述性和系统性综述，它们提供了以肥胖或食物成瘾为指标的主要定量数据。在第一轮搜索中发现了5000篇文章，被过滤到506篇文章。结果氧化应激在食物成瘾中起着关键作用，既是肥胖的原因，又是肥胖的媒介。活性氧在脂肪形成中起直接作用，氧化应激调节肥胖相关的所有因素，包括遗传，睡眠，肠道微生物组，胰岛素，生长素释放肽，炎症，脂肪因子，瘦素，应激，HPA轴和下丘脑。结论从卡路里计数，低碳水化合物，高脂或低脂，素食，纯素食，植物性或动物性饮食的角度来考虑对抗肥胖的想法是根本错误的。观察肥胖症的最佳方法是通过系统性氧化还原稳态。由于氧化还原稳态趋向于增加活性氧的产生，并且过量的抗氧化剂摄入会导致氧化应激，因此，每餐2：3的抗氧化剂和促氧化剂食物比例是保持健康和理想体重的理想营养比例。比例为3：4对肥胖的人来说是理想的选择，因为他们处于慢性氧化应激和炎症状态。身体活动，睡眠质量，心理压力，产前饮食和促进疾病的氧化应激是氧化应激和肥胖的重要调节剂。