Aging is a biological phenomenon in which the structure and function of organisms declining with the increasing of age. It has become a major risk factor of human diseases, including diabetes, cancers, cardiovascular diseases and neurodegenerative diseases. Silencing information regulator 2 related enzyme 1(sirtuin1, SIRT1) is an NAD+-dependent deacetylase, which has been reported to be involved in the regulation of cellular senescence and aging. The expression of SIRT1 is diminished with aging in mice. By contrast, increased expression of SIRT1 is sufficient to extend lifespan in yeast, caenorhabditis elegans and mice. In this review, the relationship between SIRT1 and aging and various signaling networks associated with aging, including NF-κB, AMPK, mTOR, P53, PGC1α, and FoxOs will be discussed. Meanwhile, the potential therapeutic strategies of targeting SIRT1 to anti-aging are also addressed.

中文翻译：

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SIRT1和衰老相关的信号通路。

衰老是一种生物现象，其中生物的结构和功能随着年龄的增长而下降。它已成为人类疾病的主要危险因素，包括糖尿病，癌症，心血管疾病和神经退行性疾病。沉默信息调节剂2相关的酶1（sirtuin1，SIRT1）是一种NAD +依赖性脱乙酰基酶，据报道与细胞衰老和衰老的调节有关。SIRT1的表达随着小鼠衰老而减少。相比之下，SIRT1表达的增加足以延长酵母，秀丽隐杆线虫和小鼠的寿命。在这篇综述中，将讨论SIRT1与衰老以及与衰老相关的各种信号网络之间的关系，包括NF-κB，AMPK，mTOR，P53，PGC1α和FoxO。与此同时，