The human brain is affected by cellular aging. Neurons are primarily generated during embryogenesis and early life with a limited capacity for renewal and replacement, making them some of the oldest cells in the human body. Our present understanding of neurodegenerative diseases points towards advanced neuronal age as a prerequisite for the development of these disorders. While significant progress has been made in understanding the relationship between aging and neurological disease, it will be essential to delve further into the molecular mechanisms of neuronal aging in order to develop therapeutic interventions targeting age-related brain dysfunction. In this mini review, we highlight recent findings on the relationship between the aging of nuclear structures and changes in the epigenetic landscape during neuronal aging and disease.

中文翻译：

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当功能遵循时：核室结构和衰老神经元的表观遗传景观。

人脑受到细胞衰老的影响。神经元主要在胚胎发生和早期生命期间产生，其更新和置换的能力有限，使其成为人体中最古老的细胞。我们目前对神经退行性疾病的理解指出，高级神经元年龄是这些疾病发展的先决条件。尽管在理解衰老与神经系统疾病之间的关系方面已取得了重大进展，但进一步深入研究神经元衰老的分子机制对于开发针对年龄相关性脑功能障碍的治疗性干预至关重要。在这个小型综述中，我们重点介绍了神经元衰老和疾病过程中核结构老化与表观遗传景观变化之间关系的最新发现。