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Bevacizumab has bidirectional regulatory effects on the secretion of basic fibroblast growth factor in glioma cells
Cytokine ( IF 3.8 ) Pub Date : 2020-05-01 , DOI: 10.1016/j.cyto.2020.155022
Pei Wei 1 , Zhainan Zhang 2 , Mao Lin 2 , Bin Zhou 3 , Zhiyong Wang 1
Affiliation  

Previous studies suggest that upregulated basic fibroblast growth factor (bFGF) plays a key role in the resistance to anti-vascular endothelial growth factor (VEGF) therapy in glioma. This study reported that anti-VEGF treatment regulated bFGF secretion in a double-edged manner. That is, moderate VEGF neutralization reduced bFGF production, whereas VEGF overblocking enhanced bFGF secretion in glioma cells. Our data provide a new perspective on the treatment of glioma with anti-VEGF, and the underlying mechanism is worthy of further study.

中文翻译:

贝伐单抗对胶质瘤细胞分泌碱性成纤维细胞生长因子具有双向调节作用

先前的研究表明,上调的碱性成纤维细胞生长因子 (bFGF) 在胶质瘤中对抗血管内皮生长因子 (VEGF) 治疗的抵抗中起关键作用。该研究报告说,抗 VEGF 治疗以双刃的方式调节 bFGF 的分泌。也就是说,适度的 VEGF 中和减少了 bFGF 的产生,而 VEGF 过度阻断增强了胶质瘤细胞中 bFGF 的分泌。我们的数据为抗VEGF治疗胶质瘤提供了新的视角,其潜在机制值得进一步研究。
更新日期:2020-05-01
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