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Immune-modulating and anti-inflammatory marine compounds against cancer
Seminars in Cancer Biology ( IF 14.5 ) Pub Date : 2020-02-15 , DOI: 10.1016/j.semcancer.2020.02.008
Cristina Florean 1 , Mario Dicato 1 , Marc Diederich 2
Affiliation  

The recent advances in cancer immunotherapy confirm the crucial role of the immune system in cancer progression and treatment. Chronic inflammation and reduced immune surveillance are both features of the tumor microenvironment. Strategies aimed at reverting pro-tumor inflammation and stimulating the antitumor immune components are being actively searched, and the anticancer effects of many candidate drugs have been linked to their ability to modulate the immune system. Marine organisms constitute a rich reservoir of new bioactive molecules; some of them have already been exploited for pharmaceutical use, whereas many others are undergoing clinical or preclinical investigations for the treatment of different diseases, including cancer. In this review, we will discuss the immune-modulatory properties of marine compounds for their potential use in cancer prevention and treatment and as possible tools in the context of cancer immunotherapy.



中文翻译:

抗癌免疫调节和抗炎海洋化合物

癌症免疫疗法的最新进展证实了免疫系统在癌症进展和治疗中的关键作用。慢性炎症和免疫监视减少都是肿瘤微环境的特征。目前正在积极寻找旨在逆转促肿瘤炎症和刺激抗肿瘤免疫成分的策略,许多候选药物的抗癌作用与其调节免疫系统的能力有关。海洋生物构成了丰富的新生物活性分子库;其中一些已经被开发用于药物用途,而其他许多正在接受临床或临床前研究,以治疗包括癌症在内的不同疾病。在本次审查中,

更新日期:2020-02-15
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