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Good Fences Make Good Neighbors: Crumbs Regulates Rho-Kinase Dynamics to Assemble a Tissue Boundary.
Developmental Cell ( IF 11.8 ) Pub Date : 2020-02-10 , DOI: 10.1016/j.devcel.2020.01.018
Hui-Chia Yu-Kemp 1 , Mark Peifer 1
Affiliation  

Boundary formation between nascent tissues prevents cell mixing, powering morphogenesis. In this issue of Developmental Cell, Sidor et al. (2020) describe a novel mechanism whereby the homophilic adhesion protein Crumbs regulates planar-polarized assembly of actomyosin cables at tissue boundaries by affecting dynamics of membrane recruitment of the myosin regulator Rho-kinase.

中文翻译:

良好的栅栏可以使邻居更好:碎屑调节Rho激酶的动力学,以组装组织边界。

新生组织之间的边界形成可防止细胞混合,促进形态发生。在本期《发育细胞》中,Sidor等人。(2020年)描述了一种新的机制,其中同质粘附蛋白Crumbs通过影响肌球蛋白调节剂Rho激酶的膜募集动力学,在组织边界调节放线菌素电缆的平面极化组装。
更新日期:2020-02-20
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