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De Novo Centromere Formation: One's Company, Two's a Crowd.
Developmental Cell ( IF 11.8 ) Pub Date : 2020-02-10 , DOI: 10.1016/j.devcel.2020.01.021
Beth A Sullivan 1
Affiliation  

Chromosomes containing two centromeres (dicentrics) trigger chromosome instability that is avoided by the enigmatic process of centromere inactivation. In this issue of Developmental Cell, Palladino et al. (2020) combine in vivo chromosome engineering and Drosophila genetics to assess consequences of de novo centromere formation and clarify models of centromere inactivation.

中文翻译:

De Novo Centromere的形成:一个人的公司,两个人的人群。

包含两个着丝粒(双着丝粒)的染色体会触发染色体不稳定性,而这种不稳定性可通过着丝粒失活的神秘过程避免。在本期《发育细胞》中,Palladino等人。(2020)结合体内染色体工程和果蝇遗传学来评估从头着丝粒形成的后果,并阐明着丝粒失活的模型。
更新日期:2020-02-20
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