TGF-β is long known to require Ras activation to induce EMT. In a recent issue of Nature, Massagué and colleagues (Su et al., 2020) identify RAS-responsive element binding protein 1 (RREB1) as a critical integrator of TGF-β and Ras signals during both developmental and cancer EMT programs.

中文翻译：

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RREB1整合TGF-β和RAS信号以驱动EMT。

众所周知，TGF-β需要激活Ras才能诱导EMT。在最近出版的《自然》杂志上，Massagué及其同事（Su等人，2020年）将RAS反应元件结合蛋白1（RREB1）确定为在发育和癌症EMT计划中TGF-β和Ras信号的关键整合子。