Actin has essential functions both in the cytoplasm and in the nucleus, where it has been linked to key nuclear processes, from transcription to DNA damage response. The multifunctional nature of actin suggests that the cell must contain mechanisms to accurately control the cellular actin balance. Indeed, recent results have demonstrated that nuclear actin levels fluctuate to regulate the transcriptional activity of the cell and that controlled nuclear actin polymerization is required for transcription activation, cell cycle progression, and DNA repair. Intriguingly, aberrant nuclear actin regulation has been observed, for example, in cancer, signifying the importance of this process for cellular homeostasis. This review discussed the latest research on how nuclear actin is regulated, and how this influences actin-dependent nuclear processes.

中文翻译：

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调节发育和疾病中的核肌动蛋白动力学。

肌动蛋白在细胞质和细胞核中均具有基本功能，在该细胞质中，肌动蛋白已与从转录到DNA损伤反应的关键核过程有关。肌动蛋白的多功能性质表明细胞必须包含精确控制细胞肌动蛋白平衡的机制。实际上，最近的结果表明，核肌动蛋白水平会发生波动以调节细胞的转录活性，并且转录激活，细胞周期进程和DNA修复需要受控的核肌动蛋白聚合。有趣的是，例如在癌症中已观察到异常的核肌动蛋白调节，这表明该过程对于细胞体内平衡的重要性。这篇综述讨论了有关如何调节核肌动蛋白及其对肌动蛋白依赖性核过程的影响的最新研究。