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Leveraging bias to your advantage.
Nature Chemical Biology ( IF 14.8 ) Pub Date : 2020-03-01 , DOI: 10.1038/s41589-020-0468-2
Sean P Moran 1, 2 , P Jeffrey Conn 1, 2, 3
Affiliation  

Characterization of biased receptor signaling has ushered in opportunities for unprecedented control of G-protein-coupled receptors. Elucidation of distinct M1 muscarinic acetylcholine receptor signaling pathways and development of biased ligands may offer novel and safer Alzheimer’s disease therapeutics.

中文翻译:

利用偏见发挥自己的优势。

偏向受体信号转导的表征为空前控制G蛋白偶联受体带来了机遇。阐明独特的M1毒蕈碱型乙酰胆碱受体信号通路和偏配体的发展可能提供新颖,更安全的阿尔茨海默氏病治疗方法。
更新日期:2020-02-20
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