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Oral nutritional supplements for preventing surgical site infections: protocol for a systematic review and meta-analysis.
Systematic Reviews ( IF 3.7 ) Pub Date : 2020-02-20 , DOI: 10.1186/s13643-020-01293-x
Nicholas Ralph 1, 2, 3 , Lindsay Brown 4 , Kristy L McKillop 5 , Jed Duff 6 , Sonya Osborne 7 , Victoria R Terry 1 , Karen-Leigh Edward 8 , Rachel King 9 , Edward Barui 5
Affiliation  

BACKGROUND Surgical site infections (SSIs) are among the most common healthcare-associated infections. Under-nutrition is an important risk factor for SSIs and can lead to delayed wound healing and longer hospital stays. Oral nutritional supplements are prescribed to reduce the risk of infection and improve health status, but data from randomised controlled trials (RCTs) have shown mixed results. Thus, the objective of our planned systematic review is to evaluate oral nutritional supplements on preventing SSIs in adult surgical patients METHODS: RCTs conducted in adult surgical patients who receive oral nutritional support will be included. The primary outcome will be the incidence of SSIs (within 30 days of surgery or within 90 days for joint replacement surgery). Secondary outcomes will be changes in nutritional status, mortality, health-related quality of life and costs. Literature searches will be conducted in several electronic databases (from inception onwards): MEDLINE, Embase, CINAHL and The Cochrane Central Register of Controlled Trials (CENTRAL). Grey literature will be identified through searching clinical trial registers and dissertation databases. Two reviewers will independently screen all citations, full-text articles and abstract data. The study methodological quality (or bias) will be appraised using the Cochrane risk of bias tool. If feasible, we will conduct random effects meta-analysis where appropriate. DISCUSSION This systematic review will evaluate the evidence for pre- and post-surgical intervention with oral nutritional supplements in adults. Findings from this planned review may inform subsequent nutritional interventions for hospitalised patients who undergo surgery. SYSTEMATIC REVIEW REGISTRATION PROSPERO CRD42020140954.

中文翻译:

用于预防手术部位感染的口服营养补充剂:系统评价和荟萃分析方案。

背景技术手术部位感染(SSI)是最常见的医疗保健相关感染之一。营养不良是 SSI 的一个重要危险因素,可能导致伤口愈合延迟和住院时间延长。口服营养补充剂用于降低感染风险并改善健康状况,但随机对照试验 (RCT) 的数据显示结果好坏参半。因此,我们计划的系统评价的目的是评估口服营养补充剂对预防成人手术患者 SSI 的作用。 方法:将纳入在接受口服营养支持的成人手术患者中进行的随机对照试验。主要结果是 SSI 的发生率(手术后 30 天内或关节置换手术后 90 天内)。次要结果将是营养状况、死亡率、与健康相关的生活质量和费用的变化。文献检索将在几个电子数据库中进行(从建立开始):MEDLINE、Embase、CINAHL 和 Cochrane 对照试验中央注册库 (CENTRAL)。将通过搜索临床试验登记册和论文数据库来识别灰色文献。两名审稿人将独立筛选所有引文、全文文章和摘要数据。研究方法学质量(或偏倚)将使用 Cochrane 偏倚风险工具进行评估。如果可行,我们将在适当的情况下进行随机效应荟萃分析。讨论 本系统评价将评估成人口服营养补充剂术前和术后干预的证据。这项计划审查的结果可能会为接受手术的住院患者的后续营养干预提供信息。系统审查注册 PROSPERO CRD42020140954。
更新日期:2020-04-22
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