Multi-stimuli responsive nanogels, as promising drug carriers for “on-demand” drug delivery, are expected to provide promising prospects for tumour treatment. Herein, new pH/redox/UV irradiation multi-stimuli responsive nanogels, based on polymer micelles self-assembled by six-arm star copolymer of 6AS-PCL-PAA-PPEGMA, were prepared by the complexation of ferric ions (Fe³⁺) and the carboxyl groups in the polymer micelles. The spherical structure of the polymer micelles, with particle size around 80–110 nm and zeta potential of −30.19 mV, was more conducive to crosslinking with Fe³⁺ and quickly formed nanogels with the bigger size around 150–200 nm. The DOX-loaded nanogels were obtained by introducing the anticancer drug doxorubicin (DOX) in the nanogels preparation process with a drug loading content (DLC) of 12.04%. Under the exposure to UV, an introduction of a reducing agent (GSH) and a pH response from the PAA block, the nanogels underwent decrosslinking, followed by rapid DOX release (82.1% at 116 h). Moreover, the DOX-loaded nanogels not only could be taken up quickly by HepG2 cells but also inhibited the proliferation of the cells. Hence, these results demonstrated the high potential of the prepared 6AS-PCL-PAA-PPEGMA nanogels for “on-demand” anticancer drug delivery.

作为“按需”给药的有希望的药物载体，多刺激响应纳米凝胶有望为肿瘤治疗提供有希望的前景。在此，通过三价铁离子（Fe ³⁺）的络合，制备了由6AS-PCL-PAA-PPEGMA六臂星形共聚物自组装的聚合物胶束的新型pH /氧化还原/ UV辐照多刺激响应纳米凝胶。以及聚合物胶束中的羧基。聚合物胶束的球形结构，粒径约80–110 nm，ζ电位为−30.19 mV，更有助于与Fe ³⁺交联并迅速形成尺寸在150-200 nm左右的纳米凝胶。载有DOX的纳米凝胶是通过在纳米凝胶的制备过程中引入抗癌药阿霉素（DOX）制成的，载药量（DLC）为12.04％。在暴露于紫外线下，从PAA嵌段引入还原剂（GSH）和pH响应后，纳米凝胶进行了去交联，随后迅速释放DOX（116 h时为82.1％）。此外，负载DOX的纳米凝胶不仅可以被HepG2细胞快速吸收，而且可以抑制细胞的增殖。因此，这些结果证明了制备的6AS-PCL-PAA-PPEGMA纳米凝胶具有“按需”抗癌药物递送的巨大潜力。