Innate lymphoid cells (ILCs) are tissue-resident lymphocytes that promote immunity to pathogens at mucosal barriers, but the mechanisms regulating their development within tissues remain poorly understood. In this issue of Immunity, Oherle et al. identify a niche in the neonatal airway where stromal cell-derived insulin-like growth factor 1 (IGF1) supports the proliferation of ILC precursors and protects from infection.

中文翻译：

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ILC 前体的原位支持。

先天性淋巴细胞 (ILC) 是组织驻留淋巴细胞，可促进粘膜屏障对病原体的免疫力，但调节其在组织内发育的机制仍知之甚少。在本期 Immunity 中，Oherle 等人。确定新生儿气道中的一个利基，其中基质细胞衍生的胰岛素样生长因子 1 (IGF1) 支持 ILC 前体的增殖并防止感染。