CAR T cells with different costimulation domains have proven clinical efficacy in leukemia and lymphoma but have different kinetics of activation, antigen sensitivity, and susceptibility to exhaustion. Two recent studies identified that these functions are shaped by a balance among opposing signaling complexes and transcription factors competing for binding motifs.

中文翻译：

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揭示CAR T细胞活化和衰竭的信号平衡。

具有不同共刺激结构域的CAR T细胞在白血病和淋巴瘤中已证明具有临床疗效，但具有不同的激活动力学，抗原敏感性和疲惫敏感性。最近的两项研究发现，这些功能是由相对的信号复合物和竞争结合基序的转录因子之间的平衡所决定的。