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General Anesthesia Decouples Cortical Pyramidal Neurons.
Cell ( IF 64.5 ) Pub Date : 2020-02-20 , DOI: 10.1016/j.cell.2020.01.024
Mototaka Suzuki 1 , Matthew E Larkum 1
Affiliation  

The mystery of general anesthesia is that it specifically suppresses consciousness by disrupting feedback signaling in the brain, even when feedforward signaling and basic neuronal function are left relatively unchanged. The mechanism for such selectiveness is unknown. Here we show that three different anesthetics have the same disruptive influence on signaling along apical dendrites in cortical layer 5 pyramidal neurons in mice. We found that optogenetic depolarization of the distal apical dendrites caused robust spiking at the cell body under awake conditions that was blocked by anesthesia. Moreover, we found that blocking metabotropic glutamate and cholinergic receptors had the same effect on apical dendrite decoupling as anesthesia or inactivation of the higher-order thalamus. If feedback signaling occurs predominantly through apical dendrites, the cellular mechanism we found would explain not only how anesthesia selectively blocks this signaling but also why conscious perception depends on both cortico-cortical and thalamo-cortical connectivity.

中文翻译:

全身麻醉使皮质锥体神经元解耦。

全麻的奥秘在于,即使前馈信号和基本神经元功能保持相对不变,它也可以通过破坏大脑中的反馈信号来特异性抑制意识。这种选择性的机制尚不清楚。在这里,我们显示三种不同的麻醉剂对小鼠皮质第5层锥体神经元的根尖树突沿信号传导具有相同的破坏性影响。我们发现,远端清醒的远端树突的光遗传学去极化作用在清醒条件下在细胞体上引起强烈的尖峰,并被麻醉阻滞。此外,我们发现阻断代谢型谷氨酸和胆碱能受体与麻醉或高阶丘脑失活一样,对根尖枝突脱钩的作用相同。如果反馈信号主要通过顶端树突发生,
更新日期:2020-02-20
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