A series of novel flurbiprofen-clioquinol hybrids were designed and synthesized as multifunctional agents for Alzheimer's disease therapy, and their potential was evaluated through various biological experiments. In vitro studies showed that most target compounds exhibited significant ability to inhibit self- and Cu2+-induced β-amyloid aggregation. Furthermore, some target compounds, especially 7i and 7r, also showed biometal chelating abilities, antioxidant activity, anti-neuroinflammatory activity and appropriate BBB permeability. These biological activities indicated that the representative compound 7i and 7r might be promising multifunctional agents for AD treatment.

中文翻译：

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设计，合成和评估氟比洛芬-间苯二酚杂化物作为针对阿尔茨海默氏病的多靶标定向配体。

设计并合成了一系列新型的氟比洛芬-间苯二酚杂化物作为阿尔茨海默氏病治疗的多功能剂，并通过各种生物学实验评估了它们的潜力。体外研究表明，大多数目标化合物均具有抑制自身和Cu2 +诱导的β-淀粉样蛋白聚集的显着能力。此外，一些目标化合物，特别是7i和7r，还显示出生物金属螯合能力，抗氧化剂活性，抗神经炎活性和适当的BBB渗透性。这些生物学活性表明代表性的化合物7i和7r可能是有希望的用于AD治疗的多功能剂。