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Phospholipase D as a key modulator of cancer progression
Biological Reviews ( IF 10.0 ) Pub Date : 2020-02-19 , DOI: 10.1111/brv.12592
Yuanfa Yao 1, 2 , Xinyi Wang 1, 3 , Hanbing Li 4 , Jiannan Fan 1 , Xiaohan Qian 1, 5 , Hong Li 2 , Yingke Xu 1, 2
Affiliation  

The phospholipase D (PLD) family has a ubiquitous expression in cells. PLD isoforms (PLDs) and their hydrolysate phosphatidic acid (PA) have been demonstrated to engage in multiple stages of cancer progression. Aberrant expression of PLDs, especially PLD1 and PLD2, has been detected in various cancers. Inhibition or elimination of PLDs activity has been shown to reduce tumour growth and metastasis. PLDs and PA also serve as downstream effectors of various cell‐surface receptors, to trigger and regulate propagation of intracellular signals in the process of tumourigenesis and metastasis. Here, we discuss recent advances in understanding the functions of PLDs and PA in discrete stages of cancer progression, including cancer cell growth, invasion and migration, and angiogenesis, with special emphasis on the tumour‐associated signalling pathways mediated by PLDs and PA and the functional importance of PLDs and PA in cancer therapy.

中文翻译:

磷脂酶 D 作为癌症进展的关键调节剂

磷脂酶 D (PLD) 家族在细胞中普遍存在。PLD 异构体 (PLD) 及其水解产物磷脂酸 (PA) 已被证明参与癌症进展的多个阶段。已在各种癌症中检测到 PLD,尤其是 PLD1 和 PLD2 的异常表达。已显示抑制或消除 PLD 活性可减少肿瘤生长和转移。PLD 和 PA 还作为各种细胞表面受体的下游效应器,在肿瘤发生和转移过程中触发和调节细胞内信号的传播。在这里,我们讨论了在了解 PLD 和 PA 在癌症进展的不同阶段(包括癌细胞生长、侵袭和迁移以及血管生成)中的功能方面的最新进展,
更新日期:2020-02-19
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