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Cobalt carbide-based theranostic agents for in vivo multimodal imaging guided photothermal therapy
Nanoscale ( IF 6.7 ) Pub Date : 2020/02/19 , DOI: 10.1039/d0nr00468e
Dong-Yang Zhang 1, 2, 3, 4, 5 , Han Xu 1, 2, 3, 4, 5 , Ting He 1, 2, 3, 4, 5 , Muhammad Rizwan Younis 1, 2, 3, 4, 5 , Leli Zeng 1, 2, 3, 4, 5 , Hengke Liu 1, 2, 3, 4, 5 , Chao Jiang 1, 2, 3, 4, 5 , Jing Lin 1, 2, 3, 4, 5 , Peng Huang 1, 2, 3, 4, 5
Affiliation  

Development of multifunctional theranostics is of great significance for cancer management. Herein, we develop polyethylene glycol (PEG) modified cobalt carbide nanoparticles (Co2C-PEG NPs) as cancer photothermal theranostic agents for multimodal imaging and photothermal therapy (PTT). Co2C NPs are synthesized by a high-temperature thermal decomposition method. Afterwards, the morphology, photothermal effect, multimodal imaging capacities, biocompatibility, and PTT efficacy of Co2C-PEG NPs are carefully investigated. The as-prepared Co2C-PEG NPs exhibit high photothermal conversion efficiency (PCE, η = 35.7%) and good photostability. Through photoacoustic (PA), magnetic resonance (MR), and photothermal (PT) tri-modal imaging, in vivo pharmacokinetics and tumor temperature elevation could be monitored during the PTT process. Meanwhile, the Co2C-PEG NPs also show good PTT efficacy both in vitro and in vivo. Our findings suggest that Co2C-PEG NPs are effective for cancer photothermal theranostics.

中文翻译:

用于体内多峰成像引导光热疗法的基于碳化钴的治疗剂

多功能治疗学的发展对癌症的治疗具有重要意义。本文中,我们开发了聚乙二醇(PEG)改性的碳化钴纳米颗粒(Co 2 C-PEG NPs)作为癌症光热治疗剂,用于多模式成像和光热疗法(PTT)。通过高温热分解法合成Co 2 C NP。然后,仔细研究了Co 2 C-PEG NP的形态,光热效应,多峰成像能力,生物相容性和PTT功效。所制备的Co 2 C-PEG NP表现出高的光热转化效率(PCE,η= 35.7%)和良好的光稳定性。通过光声(PA),磁共振(MR)和光热(PT)三峰成像,可以在PTT过程中监测体内药代动力学和肿瘤温度升高。同时,Co 2 C-PEG NPs在体外体内也显示出良好的PTT功效。我们的发现表明,Co 2 C-PEG NPs对癌症光热治疗是有效的。
更新日期:2020-04-03
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