Investigation of antibiotic resistance determinants and virulence factors of uropathogenic Escherichia coli.,The Journal of Antibiotics

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Investigation of antibiotic resistance determinants and virulence factors of uropathogenic Escherichia coli.
The Journal of Antibiotics ( IF 3.3 ) Pub Date : 2020-02-19 , DOI: 10.1038/s41429-020-0284-7
Ding-He Sun _{1,

2} , Ding-Feng Lv _{1,

2} , Zu-Huang Mi ₃ , Li-Qing Hu _{1,

2} , Yi Huang _{4,

5} , Xiang Gao _{4,

5} , Xing-Bei Weng _{1,

2}

Affiliation

Multidrug-resistant (MDR) uropathogenic Escherichia coli (UPEC) are prevalent throughout the world resulting in a major public health burden. In this research, we isolated and identified 28 MDR UPEC from one university hospital in China, investigated MDR and pathogenic mechanisms by PCR, including 55 antibiotic resistance determinants (ARDs) genes, 13 genetic markers of mobile genetic elements (MGEs) and 6 virulence factors (VFs) genes. In these isolates, we identified 23 ARDs genes and 6 genetic markers of MGEs that played a key role in MDR phenotypes. In addition, we found 2 VFs genes, hofQ and ompT, which could be associated with pathogenicity and invasiveness of these strains in urinary tract infections (UTIs).

更新日期：2020-02-19

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