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Urinary tract infections: microbial pathogenesis, host-pathogen interactions and new treatment strategies.
Nature Reviews Microbiology ( IF 88.1 ) Pub Date : 2020-02-18 , DOI: 10.1038/s41579-020-0324-0
Roger D Klein 1, 2 , Scott J Hultgren 1, 2
Affiliation  

Urinary tract infections (UTIs) are common, recurrent infections that can be mild to life-threatening. The continued emergence of antibiotic resistance, together with our increasing understanding of the detrimental effects conferred by broad-spectrum antibiotic use on the health of the beneficial microbiota of the host, has underscored the weaknesses in our current treatment paradigm for UTIs. In this Review, we discuss how recent microbiological, structural, genetic and immunological studies have expanded our understanding of host-pathogen interactions during UTI pathogenesis. These basic scientific findings have the potential to shift the strategy for UTI treatment away from broad-spectrum antibiotics targeting conserved aspects of bacterial replication towards pathogen-specific antibiotic-sparing therapeutics that target core determinants of bacterial virulence at the host-pathogen interface.

中文翻译:

尿路感染:微生物发病机制,宿主-病原体相互作用和新的治疗策略。

尿路感染(UTI)是常见的反复发作的感染,可能轻度威胁生命。抗生素耐药性的不断出现,加上我们对广谱抗生素使用对宿主有益菌群健康的有害影响的认识日益加深,这突出了我们目前的UTI治疗范式的弱点。在这篇综述中,我们讨论了最近的微生物,结构,遗传和免疫学研究如何扩展了我们对UTI发病机理中宿主-病原体相互作用的理解。
更新日期:2020-02-18
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