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Contrast-enhanced optical coherence tomography for melanoma detection: An in vitro study.
Journal of Biophotonics ( IF 2.8 ) Pub Date : 2020-02-26 , DOI: 10.1002/jbio.201960097
Elmira Jalilian 1 , Qiuyun Xu 2 , Luke Horton 2, 3 , Audrey Fotouhi 2, 3 , Shriya Reddy 2 , Rayyan Manwar 2 , Steven Daveluy 3, 4 , Darius Mehregan 3, 4 , Juri Gelovani 2, 4 , Kamran Avanaki 2, 3, 4
Affiliation  

Optical coherence tomography (OCT), with a high‐spatial resolution (<10 microns), intermediate penetration depth (~1.5 mm) and volumetric imaging capability is a great candidate to be used as a diagnostic‐assistant modality in dermatology. At this time, the accuracy of OCT for melanoma detection is lower than anticipated. In this letter, we studied for the first time, the use of a novel contrast agent consist of ultra‐small nanoparticles conjugated to a melanoma biomarker to improve the accuracy of OCT for differentiation of melanoma cells from nonmelanoma cells, in vitro. We call this approach SMall nanoparticle Aggregation‐enhanced Radiomics of Tumor (SMART)‐OCT imaging. This initial proof of concept study is the first step toward the broad utilization of this method for high accuracy all types of tumor detection applications.image

中文翻译:

对比增强光学相干断层扫描技术检测黑色素瘤:一项体外研究。

光学相干断层扫描(OCT)具有高空间分辨率(<10微米),中等穿透深度(〜1.5 mm)和体积成像能力,非常适合用作皮肤病学的诊断辅助模式。此时,OCT用于黑色素瘤检测的准确性低于预期。在这封信中,我们首次研究了一种新型造影剂的使用,该造影剂由与黑色素瘤生物标记物缀合的超小纳米颗粒组成,以提高OCT在体外区分黑色素瘤细胞与非黑色素瘤细胞的准确性。我们称这种方法为小纳米颗粒聚集增强的肿瘤放射学(SMART)-OCT成像。初步的概念验证研究是朝着将这种方法广泛用于所有类型的肿瘤检测应用的高精度迈出的第一步。图片
更新日期:2020-02-26
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