当前位置: X-MOL 学术Acta Physiol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Renal tubular arginase-2 participates in the formation of the corticomedullary urea gradient and attenuates kidney damage in ischemia-reperfusion injury in mice.
Acta Physiologica ( IF 6.3 ) Pub Date : 2020-02-18 , DOI: 10.1111/apha.13457
Camille Ansermet 1 , Gabriel Centeno 1 , Sylviane Lagarrigue 2 , Svetlana Nikolaeva 1, 3 , Hikari A Yoshihara 4 , Sylvain Pradervand 5 , Jean-Luc Barras 6 , Nicolas Dattner 6 , Samuel Rotman 6 , Francesca Amati 2 , Dmitri Firsov 1
Affiliation  

Arginase 2 (ARG2) is a mitochondrial enzyme that catalyses hydrolysis of l ‐arginine into urea and l ‐ornithine. In the kidney, ARG2 is localized to the S3 segment of the proximal tubule. It has been shown that expression and activity of this enzyme are upregulated in a variety of renal pathologies, including ischemia‐reperfusion (IR) injury. However, the (patho)physiological role of ARG2 in the renal tubule remains largely unknown.

中文翻译:

肾小管精氨酸酶2参与了皮质肾小球尿素梯度的形成,并减轻了小鼠缺血再灌注损伤中的肾脏损害。

精氨酸酶2(ARG2)是一种线粒体酶,催化l-精氨酸水解为尿素和l-鸟氨酸。在肾脏中,ARG2位于近端小管的S3段。研究表明,该酶的表达和活性在包括缺血再灌注(IR)损伤在内的多种肾脏疾病中均被上调。但是,ARG2在肾小管中的(病理)生理作用仍然未知。
更新日期:2020-02-18
down
wechat
bug