The HPTN 071 (PopART) trial evaluated the impact of an HIV combination prevention package that included “universal testing and treatment” on HIV incidence in 21 communities in Zambia and South Africa during 2013‐2018. The primary study endpoint was based on the results of laboratory‐based HIV testing for> 48,000 participants who were followed for up to three years. This report evaluated the performance of HIV assays and algorithms used to determine HIV status and identify incident HIV infections in HPTN 071, and assessed the impact of errors on HIV incidence estimates.

中文翻译：

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在一项大型社区随机试验中确定 HIV 状态并识别 HIV 感染事件：HPTN 071 (PopART)

HPTN 071 (PopART) 试验评估了包括“普遍检测和治疗”在内的 HIV 联合预防方案对 2013-2018 年赞比亚和南非 21 个社区的 HIV 发病率的影响。主要研究终点基于对超过 48,000 名参与者进行了长达三年的实验室 HIV 检测结果。本报告评估了用于确定 HIV 状态和识别 HPTN 071 中发生的 HIV 感染的 HIV 检测和算法的性能，并评估了错误对 HIV 发病率估计的影响。