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C2-H Arylation of Indoles Catalyzed by Palladium-Containing Metal-Organic-Framework in γ-Valerolactone.
ChemSusChem ( IF 8.4 ) Pub Date : 2020-02-15 , DOI: 10.1002/cssc.202000378
Ioannis Anastasiou 1 , Niels Van Velthoven 2 , Elena Tomarelli 1 , Aurora Lombi 1 , Daniela Lanari 3 , Pei Liu 4 , Sara Bals 4 , Dirk E De Vos 2 , Luigi Vaccaro 1
Affiliation  

An efficient and selective procedure was developed for the direct C2-H arylation of indoles using a Pd-loaded metal-organic framework (MOF) as a heterogeneous catalyst and the nontoxic biomass-derived solvent γ-valerolactone (GVL) as a reaction medium. The developed method allows for excellent yields and C-2 selectivity to be achieved and tolerates various substituents on the indole scaffold. The established conditions ensure the stability of the catalyst as well as recoverability, reusability, and low metal leaching into the solution.

中文翻译:

γ-戊内酯中含钯金属有机骨架对吲哚的C2-H芳基化反应

利用负载钯的金属-有机骨架(MOF)作为非均相催化剂,无毒生物质衍生的溶剂γ-戊内酯(GVL)作为反应介质,开发了一种高效且选择性的程序,用于吲哚的直接C2-H芳基化。所开发的方法可实现优异的收率和C-2选择性,并能耐受吲哚支架上的各种取代基。既定条件确保了催化剂的稳定性以及可回收性,可重复使用性和低金属浸入溶液中。
更新日期:2020-02-15
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