The gut microbiome has pervasive bidirectional relationships with pharmacotherapy, chronic disease, and physical and cognitive function. We conducted a narrative review of the current literature to examine the relationships between the gut microbiome, medication use, sarcopenia and frailty, and cognitive impairment. Data from in vitro experiments, in vivo experiments in invertebrates and complex organisms, and humans indicate associations between the gut microbiome and geriatric syndromes. Better understanding of the direct and indirect roles of the microbiome may inform future prevention and management of geriatric syndromes.

中文翻译：

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老化的肠道微生物群与常见的老年巨人之间的相互作用：多药、虚弱和痴呆

肠道微生物组与药物治疗、慢性疾病以及身体和认知功能有着广泛的双向关系。我们对当前文献进行了叙述性审查，以检查肠道微生物组、药物使用、肌肉减少症和虚弱以及认知障碍之间的关系。来自体外实验、无脊椎动物和复杂生物体内实验以及人类的数据表明肠道微生物群与老年综合征之间存在关联。更好地了解微生物组的直接和间接作用可能为未来老年综合征的预防和管理提供信息。